to FECAVA News

View other issues

of EJCAP online

Give your feedback


Volume 24(1), Spring 2014

Reprint paper (SVK/ASMPA)

Spindle toxins as chemotherapeutic agents in veterinary medicine

by Valeria Meier and Carla Rohrer Bley

Mitosis and microtubules

Microtubules are found in all eukaryotic cells and are responsible for various mechanisms of actions of a cell such as the formation of the spindle apparatus during cell division, ...

... Read more




... Read more

Spindle toxins

Spindle toxins disturb the balance of the dynamic processes of microtubules by either excessively stabilising the microtubules, i.e. promoting microtubule polymerisation, or by destabilising them, which happens through ...

... Read more

Spindle toxins belong to the most potent agents in the fight against cancer as their effect is based on direct interference with the cell cycle. Their main targets are the microtubules, which are essential for ...

Read more ...