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Volume 24(1), Spring 2014

Reprint paper (SVK/ASMPA)

Spindle toxins as chemotherapeutic agents in veterinary medicine

by Valeria Meier and Carla Rohrer Bley

Mitosis and microtubules

Microtubules are found in all eukaryotic cells and are responsible for various mechanisms of actions of a cell such as the formation of the spindle apparatus during cell division, ...

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Inhibiting

proliferation

 

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Spindle toxins

Spindle toxins disturb the balance of the dynamic processes of microtubules by either excessively stabilising the microtubules, i.e. promoting microtubule polymerisation, or by destabilising them, which happens through ...

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Spindle toxins belong to the most potent agents in the fight against cancer as their effect is based on direct interference with the cell cycle. Their main targets are the microtubules, which are essential for ...

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