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Prior history of anti-inflammatory drug administration and location of gastrointestinal perforation in 55 dogs and cats
Prior history of anti-inflammatory drug administration and outcome in 55 dogs and cats
The impact of NSAIDs
Although no significant association was found between prior drug history and outcome or survival at 24 hours, only 2 of 15 (13.3%) animals with a history of anti-inflammatory drugs survived compared to 14 of 36 (38.8%) animals not receiving anti-inflammatory drugs.
Prior treatment with anti-inflammatory drugs was, however, significantly (P=0.0011) associated with perforation of the pylorus (11 of 19 (57.9%)) compared to perforation at other GI sites (4 of 32 (12.5%)).
Objectives: To identify potential prognostic factors affecting outcome in septic peritonitis caused by gastrointestinal perforation in dogs and cats.
Methods: A retrospective study. Animals operated on for septic peritonitis because of gastrointestinal perforation were evaluated. Risk factors assessed included age, duration of clinical signs, recent prior abdominal surgery, recent prior anti-inflammatory drug administration, placement of a closed-suction drain and location of perforation.
Results: Fifty-five animals (44 dogs and 11 cats) were included. The overall mortality was 63.6%. No association was found between age, duration of clinical signs or prior abdominal surgery and outcome. Animals with a history of prior anti-inflammatory drugs were significantly (P=0.0011) more likely to have perforation of the pylorus (73.3%). No significant difference in outcome was found between animals treated with closed-suction drains and those treated with primary closure or between pyloric perforation and perforation at other gastrointestinal sites.
Clinical Significance: Administration of anti-inflammatory drugs in dogs and cats is a significant risk factor for pyloric perforation. Pyloric perforation was not associated with a poorer outcome than perforation at other gastrointestinal sites. Placement of a closed suction drain did not improve outcome compared to primary closure.
* This paper originally appeared in the Journal of Small Animal Practice (2013) 54,
625–629 DOI: 10.1111/jsap.12151
Thomas Dayer DVM DipECVS
Vet. Avenir Sàrl
Route du Reposoir 1
Thomas Dayer graduated from the University of Bern Veterinary Faculty in 2008. After graduation he remained at the University’s Tierspital in Berne where he completed an internship and a residency in small animal surgery to become a diplomate of the European College of Veterinary Surgeons. Upon completing his residency he became head of the surgical unit for one year. In 2014, he left academia and joined a private practice in the west of Switzerland, to develop the surgical department and to introduce arthroscopy and laparoscopy to the practice.
Volume 26(3), Autumn 2016
Septic peritonitis from pyloric and non-pyloric gastrointestinal perforation:
prognostic factors in 44 dogs and 11 cats
by Thomas Dayer, Judith Howard and David Spreng
The impact of NSAIDs
Although no significant association was found between prior drug history and outcome or survival at 24 hours, only 2 of 15 (13.3%) ...
... Read more
No difference in survival was found between animals treated with closed suction drains and those treated with primary abdominal closure.
Objectives: To identify potential prognostic factors affecting outcome in septic peritonitis caused by gastrointestinal perforation in dogs and cats. ...
... Read More