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Volume 23-1, Spring 2013

Reprint paper

Treating dogs with IMHA

Evaluation of immunosuppressive regimens for

immune-mediated haemolytic anaemia:

a retrospective study of 42 dogs

by James Swann and Barbara Skelly

OBJECTIVES: Immune-mediated haemolytic anaemia (IMHA) is a severe disease for which evidence is lacking to make informed choices regarding immunosuppressive regimen. The aims of the current study were to determine the effect of different treatment regimens on outcome in affected animals and to identify parameters that may be used as prognostic factors for the disease.

 

METHODS: The records of dogs presenting to a veterinary hospital in the period 2002 to 2010 for treatment of IMHA were examined and follow-up data were obtained. Statistical tests were performed to establish whether treatment regimen affected outcome and to identify prognostic factors for outcome. ...

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The Kaplan-Meier curve of the study population shows a lower survival for the group treated with cyclosporine and prednisolone than the other treatment groups.

But although treatment regimen had a significant effect on the outcome (measured as survival of hospitalisation), there were insufficient subjects to determine the cause of the difference.

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A quick reminder

Immune-mediated haemolytic anaemia (IMHA) is the result of a type II (antibody-mediated) autoimmune response directed at antigens expressed on the surface of erythrocytes.

The cause is unknown, although certain subtypes of the disease ...

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